For example, TGFβ-1 treatment of hepatocellular carcinoma cells and osteoarthritic fibroblasts leads to increased expression of specific cross-linking enzymes from the LOXL and LH families [32,33], while similar treatment of dermal fibroblasts increased the expression and activity of TG2 [29]. Here, TGFB1 is linked to hepatocellular carcinoma.