Also WA regulates the activity of antioxidant enzymes (such as superoxide dismutase) [38] and mRNA expression of antioxidant genes: erythroid 2-like 2 (NFE2L2), heme oxygenase 1 (HMOX1), glutathione-disulfide reductase (GSR), and NAD(P)H quinone dehydrogenase 1 (NQO1)) in cancer cells [39]. This evidence concerns the gene HMOX1 and cancer.