Alterations in the following genes have been implicated as CH in some circumstances: ASXL1, ATM, BCOR, CALR, CBL, CEBPA, CREBBP, DNMT3A, ETV6, EZH2, FLT3, GNAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL, MYD88, NPM1, NRAS, PPM1D, RUNX1, SETD2, SF3B1, SH2B3, SRSF2, STAG2, STAT3, TET2, TP53, U2AF1, WT1, and ZRSR2. 14, 15In general, the prevalence of CH mutations increases with age and is over 7% in people aged 60 years or older without a detectable solid or hematologic malignancy.15, 16, 17. Here, C4B is linked to hematologic disorder.