As previously demonstrated in the context of imiquimod-induced dermatitis (11), dysregulated production of TNF in the absence of TTP in epidermal cells was responsible for increased expression of inflammatory mediators and recruitment of innate immune cells during carcinogenesis; conversely, regulated TTP overexpression resulted in decreased skin infiltration of immune cells in this model (13). The gene discussed is ZFP36; the disease is dermatitis.