Indeed, several of the immunodominant regions we have identified experimentally in the structural proteins of endemic HCoVs are orthologous to the regions thought to be immunodominant targets for immune responses to SARS-CoV-2 (42) (Supplemental Figure 8), including 2 linear epitopes on the SARS-CoV-2 S protein that elicit potent neutralizing antibodies in COVID-19 patients (56). The gene discussed is PROS1; the disease is COVID-19.