Alzheimer’s Disease (AD) has also been well-established in Down syndrome (DS) [3, 4], although not everyone with DS develops AD symptoms, autopsy studies have shown that by age of 40 years old, the brains of almost all individuals with DS have significant levels of beta-amyloid plaques and tau tangles, abnormal protein deposits considered AD hallmarks [5]. Here, MAPT is linked to Alzheimer disease.