Our resultsare in accordance with the findings reported by Samimi et al. (19) which showed that the useof one synbioticcapsules (genera Lactobacillus Lactobacillus acidophilus, L.casei, and B. bifidum, 2×109 CFU/g together with 800mg inulin) per day for 12 weeks, reduced serum insulin and HOMA-IR in PCOS women.Esmaeilinezhad et al. (29) reported that consumption of synbiotic pomegranate juice andsynbiotic beverage (2 L/week) for 8 weeks, lowered HOMA-IR in women with PCOS. This evidence concerns the gene INS and polycystic ovary syndrome.