TTR and primary systemic amyloidosis: Levels of amyloid protein are the most important factor for progression of amyloidosis, and suppression of amyloid protein levels is the main target for treatment of various systemic amyloidosis, including AA, AL, ATTR, and dialysis-related Aß2M amyloidosis (Merlini and Bellotti, 2003; Knowles et al., 2014; Calhoun et al., 1999; Zhang et al., 2010; Ueda et al., 2007).