DICER1 and multinodular goiter: Based on the chromosomal location and the type of lesions (multinodular goiter in childhood, beningn thyroid tumors, differentiated thyroid cancer, rhabdomyosarcoma, as well as ovarian and brain tumors) described in these families [79], we think that at least some cases are secondary to germline DICER1 gene mutation [107] (see DICER1 syndrome below).