Nuclear FOXE1 immunoexpression in tumor cells in the vicinity of the PTC border is associated with the presence of a risk allele of rs1867277 (c.-238G>A) in the 5′ untranslated region of the FOXE1 gene, as well as with pathological characteristics (multifocality and capsular invasion) of PTC, suggesting possible FOXE1 involvement in the facilitation of tumor development [86]. The gene discussed is FOXE1; the disease is neoplasm.