Some of them are hepatocyte growth factor targeting and induction of apoptosis in human hepatocellular carcinoma (HCC), induction of cell death via the mediation of the epidermal growth factor receptor (EGFR) signaling pathway, regulation of AMP-activated protein kinase (AMPK) and increment in cell apoptosis induced by cisplatin [48–50]. This evidence concerns the gene HGF and hepatocellular carcinoma.