ITIH3 and schizophrenia: Meanwhile, in a pooled population of bipolar and schizophrenia patients, an association was demonstrated [26] with rs736408 (Chr3) in the intron region of ITIH3. Of note, for rs10994415, rs9371601, and rs7296288 (NC_000012.11:g.49479968A>C) that exceeded the genome-wide significant level, several studies [29, 30] investigated biological mechanism.