Interestingly, the only study including patients with VLCAD, LCHAD, TFP, and CPT-2 deficiencies identified both by NBS and clinically demonstrated higher mortality in NBS-identified patients (67% vs. 0%, respectively), but the sample size was limited to three and two patients in each cohort.46 No studies reporting mortality in NBS-identified patients with CACT deficiency were available for comparison. Here, CPT2 is linked to hyperinsulinemic hypoglycemia, familial, 4.