After WT, C6st-1 HE, and C6st-1 KO mice were treated with IMQ for 3 days, the K14-positive basal layer was markedly thicker in C6st-1 HE and C6st-1 KO mice than in WT mice (Fig. 8f, g). The gene discussed is CHST3; the disease is hereditary elliptocytosis.