The gene expression levels of filaggrin, occludin, claudin 1, claudin 5, loricrin, and transglutaminase 1 were significantly decreased in C6st-1 HE and C6st-1 KO mice compared with those in C6st-1 WT mice (Fig. 3d). The gene discussed is CLDN5; the disease is hereditary elliptocytosis.