CANX and Hyperglycemia: Down-regulated gene sets included those associated with extracellular matrix interactions, chaperone function, calnexin/calreticulin cycle, N-glycan trimming and peptide chain elongation (Fig. 2A), while gene sets upregulated in response to hyperglycaemia included cholesterol biosynthesis, complement cascade and fibrin clotting cascade (Fig. 2B–D).