Three of these glioma-associated SNPs were pleiotropic: RTEL1 (rs1291209: allergic disease asthma hay fever or eczema), CDKN2B (rs6475604: coronary heart disease, glaucoma, vertical cup disc ratio), and PHLDA1 (rs1565765: atrial fibrillation) (Supplementary Dataset 8). This evidence concerns the gene RTEL1 and seasonal allergic rhinitis.