TNF and inflammatory bowel disease: This SNP falls within a three-species conserved, top-ranked pre- and post-TNFα RELA peak, and has been associated with coronary artery disease88, allergic disease89, pleiotropic chronic inflammatory disease86, IBD (14 GWAS studies), pediatric autoimmune disease, thyroid cancer (5 studies), and ulcerative colitis (12 studies) (Supplementary Dataset 8).