Of note, the impact of YAP1 on cellular senescence is still controversial, as some studies have demonstrated that depletion of YAP is sufficient to cause senescence-associated phenotypes in mesenchymal stem cells or breast cancer cells11,50, while others have found that hyperactivation of YAP1 induces senescence in cultured primary human ovarian surface epithelial cells13. The gene discussed is YAP1; the disease is breast cancer.