Cav1-deficient (Cav1−/− or Cav1-KO) mice are viable and fertile, and abnormal brain vascular phenotypes have not been reported although Cav1-KO mice exhibited pulmonary fibrosis, hypertension, or cardiac hypertrophy as well as retinal vascular permeability29. The gene discussed is CAV1; the disease is pulmonary fibrosis.