Moreover, Cav1 deletion in Pdcd10BECKO mice (DKO) significantly reduced the number of lesions and capillary dilation of CCM lesions induced by Ccm3 deletion as visualized by whole-brain imaging and H&E staining in the cerebellar sections from the DKO mice compared to Pdcd10BECKO mice (Fig. 6a–c; Supplementary Fig. 8 for retina). Here, PDCD10 is linked to cerebral cavernous malformation.