To the best of our knowledge, this is the first study to show that the inflammatory microenvironment of the liver can promote the proliferation, metastasis, and EMT of LUAD cells via the METTL3-mediated m6A methylation of YAP1. In terms of m6A, this study elucidated the regulatory and molecular mechanism by which the hepatic inflammatory microenvironment regulates the biological function of LUAD cells, which provides a new research strategy for the early diagnosis, treatment, and prognosis of lung cancer. The gene discussed is YAP1; the disease is lung cancer.