In the tumor microenvironment, inflammatory cytokines, such as TNFα, TGFβ, IL-1β, IL-6, and IL-12, can regulate critical EMT transcription factors, including zinc finger E-Box-binding homeobox (ZEB1), ZEB2, the zinc finger protein Snail/Slug, and the helix spiral transcription factor Twist, thus initiating the EMT program [25]. The gene discussed is TWIST1; the disease is neoplasm.