HIPK3 and nonpapillary renal cell carcinoma: The results showed that HIPK3 could distinguish ccRCC cancer from normal tissues statistically and produce the area under the curve (AUC) of 0.8144 (95% CI: 0.7678-0.8610; p < 0.0001, Figure 6A), ccRCC of para-normal tissue with AUC of 0.7567 (95% CI: 0.6775-0.8368; p < 0.0001, Figure 6B).