In addition, a subgroup ROC curve analysis of clinical characteristics suggests that low expression of HIPK3 may have diagnostic value in ccRCC patients with living vs deceased (AUC = 0.6397, 95% CI: 0.5893-0.6900, p < 0.0001, Figure 6C), recurred vs disease free (AUC = 0.6128, 95% CI: 0.5555-0.6702, p=0.0002, Figure 6D), M1 / M0 stage (AUC = 0.5929, 95% CI: 0.5175-0.6587, p=0.008, Figure 6E), (T3 + T4) / (T1 + T2) (AUC = 0.5750, 95% CI: 0.5244-0.6256 p=0.004, Figure 6F), pathological stage (III + IV)/ (I + II) (AUC = 0.6012, 95% CI: 0.5516-0.6206, p < 0.0001, Figure 6G). This evidence concerns the gene HIPK3 and nonpapillary renal cell carcinoma.