PLK1 and endometrial cancer: Furthermore, GSVA analysis of TICRR confirmed that E2F mediated regulation of DNA replication, RHO GTPases activity and mitotic G1/S phrase pathway were remarkably statistically significant in the high-expression groups of TICRR (Figure 9E) and MAPK3/ERK1 activation and regulation of PLK1 at G2/M transition pathway were activated in high-expression groups of PPIF (Figure 9F), suggesting their involvement in the cell cycle transition and proliferative processes in progression of endometrial cancer.