Based on previous studies, TICRR, a crucial checkpoint and replication modulator [26], contributed to the occurrence of tumor through promoting DNA replication and cyclin-dependent kinase regulated the length of S phase by TICRR/TRESLIN phosphorylation in tumor [27], which were consistent with our GSEA and GSVA analysis but had not been validated in related study of endometrial cancer. Here, TICRR is linked to endometrial cancer.