As shown in Figure 4A–4C, the phospho-Thr308 and phospho-Ser473 Akt expression level was remarkably decreased when PRMT5 was down-regulated in HCT116 and SW480 cells, implying that PRMT5 controlled colorectal cancer cell proliferation and cell cycle progression through regulation of Akt activity. Here, AKT1 is linked to colorectal cancer.