It has been reported that in tamoxifen-resistant breast cancer cells, knockout of ESRP1 could affect lipid metabolism and oxidoreductase processes, and increase cell basal and standby respiration capabilities, suggesting that ESRP1 may be a potential molecule for preventing drug resistance in ER+ breast cancer cells, analysis the role of ESRP1 in chemoresistance from glycolysis pathway [37]. The gene discussed is ESRP1; the disease is breast cancer.