Since ESRP1 reduced the ratio of CARM1FL to CARM1ΔE15, in order to further examine the different roles of CARM1FL and CARM1ΔE15 in regulating chemoresistance of SCLC, we designed specific siRNAs targeting CARM1FL and CARM1ΔE15 transcripts respectively. Here, ESRP1 is linked to small cell lung carcinoma.