We detected the content of two splice isoforms of CARM1 in SCLC cells, and found that the content of CARM1FL in chemoresistant cells was significantly higher than that in chemosensitive cells, whereas the content of CARM1ΔE15 was completely opposite; this suggested that the alternative splicing of CARM1 is related to the chemoresistance of SCLC (Figure 4G). Here, CARM1 is linked to small cell lung carcinoma.