The IHC results revealed that these four candidate proteins were upregulated in CRC to varying degrees (Figure 1B–1D), but only TRIM29 expression was associated with lymph node metastasis (Figure 1E, P=0.018), advanced stage (Figure 1F, P<0.001) and poor prognosis of CRC (Figure 1G, P=0.005). This evidence concerns the gene TRIM29 and colorectal carcinoma.