Among the four genes, C2orf27A has not been previously reported in HCC, whereas IGF2R is reportedly related to HCC progression, particularly in regard to transarterial chemoembolisation (TACE) treatment prior to surgery, with TACE-pretreated HCC patients showing significantly higher IGF2R mRNA expression in tumor tissues [26]. The gene discussed is IGF2R; the disease is hepatocellular carcinoma.