RFC1 and Gait ataxia: Onset of gait ataxia in patients with RFC1 repeat expansions occurred at a median age of 53 years (range 32–72 years, IQR 49–60 years) (figure 6A) and was earlier in patients with chronic cough (n = 46, age 50.3 ± 7.3 years) than without chronic cough (n = 19, age 61.7 ± 7.4 years, t test, p < 0.001).