GRIN2B and Alzheimer disease: For example, rs1806201, which is within exon 13 of the NR2B gene locus, may play a role in modulating susceptibility to AD (Andreoli et al., 2014), and the frequency of the Ht2-AG haplotype in the NR3A gene may also be higher in AD patients, indicating that NR3A variants may increase the risk of AD (Liu et al., 2009).