For example, rs1806201, which is within exon 13 of the NR2B gene locus, may play a role in modulating susceptibility to AD (Andreoli et al., 2014), and the frequency of the Ht2-AG haplotype in the NR3A gene may also be higher in AD patients, indicating that NR3A variants may increase the risk of AD (Liu et al., 2009). Here, GRIN3A is linked to Alzheimer disease.