Yeh et al. (2011) analyzed astroglia morphology in the EC through surface and volume measurements of GFAP profiles in a triple transgenic mouse model of AD which harbours APPswe, PS1M146V and TauP301L mutations (3xTg-AD), and found that both the surface and volume of astroglia were reduced as compared to controls at a very early age (1 month). This evidence concerns the gene GFAP and Alzheimer disease.