MUC1 and breast cancer: Analysis of the independent METABRIC cohort of BC tissues (n=1904) similarly revealed significant depletion of immune cell infiltrates in MUC1-high relative to MUC1-low tumors (n=476 per group), specifically CD8 +T cells (p=9.55e-19), CD8 +naive T cells (3.38e-14), B cells and Th2 cells among others (figure 4C, D and online supplemental table S3).