Second, sense and antisense RNA transcripts from mostly nuclear RNA foci in C9orf72 ALS and FTD (Balendra and Isaacs, 2018; DeJesus-Hernandez et al., 2011; Donnelly et al., 2013; Gendron et al., 2013; Lagier-Tourenne et al., 2013; Lee et al., 2013; Mizielinska et al., 2013; Vatovec et al., 2014; Zu et al., 2013). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.