TDP-43 and FUS are RNA-binding proteins that play a role in multiple RNA processing and metabolic pathways and form cytoplasmic inclusions and nuclear depletion in ALS and FTD (Gao et al., 2017; Kwiatkowski et al., 2009; Ling et al., 2013; Mitchell et al., 2013; Neumann et al., 2009; Rogelj et al., 2012; Sreedharan et al., 2008; Štalekar et al., 2015; Vance et al., 2009). This evidence concerns the gene TARDBP and frontotemporal dementia.