Consistent with the phenotypical defects observed in Nrg4 knock-out neurons, the clusters with similar levels of receptor and ligand co-expression are defined by markers related to cytoskeletal dynamics, synaptic function, dendritic arborization and spine formation, migration and axonal development, and have been reported to be altered in neurodevelopmental disorders. The gene discussed is NRG4; the disease is neurodevelopmental disorder.