SARS-CoV-2 increases interferon gamma, tumor necrosis factor-α, macrophage inflammatory protein-1 alpha, IL-2, IL-6, IL-7, IL-10, in patients, that show a form of secondary hemophagocytic lymphohistiocytosis or macrophage activation syndrome (sHLH/MAS). The gene discussed is TNF; the disease is macrophage activation syndrome.