In addition, sepsis-AKI patients showed an increased expression of hypoxia-inducible factor 1-alpha (HIF1α), the master oxygen sensor within cells and manganese superoxide dismutase (mnSOD), a key antioxidant enzyme, suggesting an active response to oxidative stress (both p < 0.001; Fig. 3c, d). The gene discussed is SOD2; the disease is acute kidney injury.