Statistically, higher serum survivin concentration was observed among children with JIA and the presence of anti-CCP antibodies (ACPA) in comparison with anti-CCP-negative patients (Me 66.98 pg/ml (IQR 25.77–105.47) vs Me 22.61 pg/ml (IQR 17.37–27.89); p = 0.001) (Fig. 3). Here, BIRC5 is linked to juvenile idiopathic arthritis.