TP53 and gastric cancer: The four major genomic subtypes of GC categorized by TCGA include tumors positive for (1) Epstein-Barr virus (EBV), (2) microsatellite instability (MSI), (3) chromosomal instability (CIN), and (4) genome stability (GS), while the ACRG proposed (1) MSI, (2) microsatellite stability (MSS)/epithelial-mesenchymal transition (EMT), (3) MSS/TP53(+), and (4) MSS/TP53(−) with distinct survival outcomes.