Several recent studies have revealed that FABP 4 expression in EAT was strongly associated with the extent of atherosclerosis in coronary artery disease patients with metabolic syndrome [27], and annexin-A2/fetuin-A signaling in EAT was linked to the pathophysiology of coronary atherosclerotic calcification in elderly patients with coronary artery disease [28]. This evidence concerns the gene ANXA2 and coronary artery disorder.