However, the effect on NT-proBNP level between the SGLT2i and control group was − 333 pg/ml in the T2DM subgroup in the DAPA-HF trial [10] (median baseline level in the SGLT2i group: 1479 pg/ml), and − 103 pg/ml in the whole population of EMPEROR-Reduced trial [42] (median baseline level in the SGLT2i group: 1894 pg/ml) declaring no significant difference in patients with and without T2DM. This evidence concerns the gene NPPB and hydrops fetalis.