NPPB and hydrops fetalis: The use of SGLT2i reduced the NT-proBNP level in stage C HF population (SMD − 0.12, 95% CI − 0.20 to − 0.05, p = 0.002; I2 = 0%) but not in stage A–B HF population (SMD − 0.02, 95% CI − 0.14 to 0.09, p = 0.69; I2 = 0%) (Fig. 4).