It can not only inhibit the apoptosis and proliferation of numerous malignant cells, including BC and tumor growth in animal models through multiple signaling pathways [37], such as the AMPK [38], PI3K/Akt [39], and JNK pathways [40], but can also enhance the sensitivity of other anti-cancer agents and reverse the drug resistance of cancer cells [40]. Here, AKT1 is linked to neoplasm.