CXCL10 and infection: In the supernatants collected from the three successful replications, a significant increase in CXCL10 secretions at 72 hpi was observed, particularly in the CUHK-ED-2 lines, indicating that the infection of HuNoV in HIE could induce CXCL10 secretion, whereas in the unsuccessful case (CUHK-ED-3 inoculated with CUHK-NS-1190), there was no change in the CXCL10 secretion at different time points (Figure 6a).