Several nitrogen-based heterocyclic drugs have been used to inhibit VEGF, for example, agents that inhibit the VEGFR tyrosine kinase such as the pyrrolidinone-based Sunitinib were approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor [35,36]. This evidence concerns the gene VEGFA and renal cell carcinoma.