In addition, it was clarified that the skin of pigs with experimentally induced type 1 diabetes has a lower AQP3 compared to non-diabetic pigs, that wound healing is delayed in diabetes model pigs, and that topical treatment of erythropoietin accelerates wound healing and this effect depends on the increase of AQP3 [43]. The gene discussed is EPO; the disease is type 1 diabetes mellitus.