Additionally, Fn14 is highly expressed in the metastases of breast, colorectal, melanoma, non-small cell lung, and prostate cancer [6] and reported to play a role in muscle wasting and cachexia [16,17] as well as in chronic human inflammatory pathologies such as neurodegenerative, autoimmune, or malignant diseases [18]. This evidence concerns the gene TNFRSF12A and melanoma.