TSPY1 and goblet cell carcinoma: The co-presence and aberrant expression of testis-specific protein Y-encoded (TSPY) located on the short arm of the human Y-chromosome and the pluripotency factor Octamer Binding Protein 3 Transcription Factor 4 (OCT3/4) is hypothesized to increase the risk for malignant GCC development [30,31,32].