Likewise, silencing the expression of HSP27 and HSP72 in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells makes them extremely vulnerable to apoptosis induced by temozolomide and/or quercetin, and soluble epoxide hydrolase inhibitor (sEHi) trans-4[-4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB)-induced autophagy in glioblastoma U251 and U87 cells was also blocked by the inhibition of Hsp27 with quercetin [65,67]. The gene discussed is EPHX2; the disease is glioblastoma.