Further, infusion of pyrrolidine dithiocarbamate (PDTC), a different compound that also inhibits NF-κB, into the hypothalamic PVN hinders the development of high-salt-induced hypertension through the NLRP3 inflammasome and caspase-1 pathway [163], highlighting the possible relevance of preventing the development of hypertension by inhibiting NF-κB and caspase-1 activity at hypothalamic levels. Here, CASP1 is linked to hypertensive disorder.