Chronic inhibition of NF-κB activity in the hypothalamic paraventricular nucleus (PVN) has been proven to delay the development of hypertension by upregulating anti-inflammatory cytokines, reducing NLRP3 and IL-1β expression and attenuating the enzymatic activity of the activated inhibitor of nuclear factor NF-κB kinase β (p-IKKβ, NF-κB p65) and NAD(P)H oxidase in the PVN of salt-sensitive hypertensive rats [163]. This evidence concerns the gene NFKB1 and hypertensive disorder.