Moreover, a recent study reports that ELABELA, a 32-residue hormone peptide, mitigates hypertension by attenuating the NADPH oxidase/ROS/NLRP3 inflammasome axis in human renal tubular cells stimulated with aldosterone, thus demonstrating the role of ROS in NLRP3 activation and blood pressure regulation in the kidneys [193]. Here, FMO5 is linked to hypertensive disorder.