Elevated activation levels of the key NLRP3 inflammasome priming factor, NF-κB, in tissue and inflammatory cells are persistent in hypertension [102,103] and result in exaggerated levels of circulating and tissue IL-1β and IL-18 in patients with essential hypertension and in animal models of the disease [104,105]. This evidence concerns the gene NFKB1 and hypertensive disorder.