SNCA and Parkinson disease: Caspase 1 can be activated by known inflammasome-stimulators to directly cleave α-synuclein to generate truncated species that are prone to form aggregates in a neuronal PD cell model, and silencing of caspase 1 expression rescues neurotoxicity caused by α-synuclein, suggesting that under certain toxic stimuli, inflammasome, and caspase 1 cause PD pathology in neurons [53].