IL4 and allergic disease: Hong and colleagues determined that the diterpenoid hipposponlachnin B (153) isolated from the South China Sea marine sponge Hippospongia lachne decreased production of β-hexosaminidase, a degranulation biomarker and pro-inflammatory mediators IL-4 and LTB4 by RBL-2H3 cells, suggesting a possible therapeutic use for “the treatment of allergy” [181].