ACHE and Alzheimer disease: Adelhameed and colleagues reported the isolation and structure elucidation of a new phytoceramide MEC-1-4 (217) from the Egyptian Red Sea sponge Mycale euplectellioides that moderately inhibited acetylcholinesterase by interacting with the enzyme “via hydrogen bonding, hydrophobic contacts and hydrophilic-hydrophobic interactions”, thus suggesting MEC-1-4 might become a “valuable lead compound for AD management” [238].