Botic Lee and colleagues discovered that the brominated alkaloid discorhabdin G (213) isolated from the Antarctic Latrunculia biformis sponge inhibited electric eel and human acetylcholinesterases by a reversible and competitive mechanism, observations that could potentially lead to new Alzheimer’s disease “cholinesterase inhibitors based on the scaffold of discorhabdins” [231]. Here, ACHE is linked to Alzheimer disease.