KRAS and HIV-1 infection: MCCC 3A00281 moderately inhibited in vitro HIV-1 infection [115]; a tricyclic anthraquinone ω-hydroxyemodin (118) isolated from the Red Sea brown alga Padina pavonica-derived fungus Fusarium equiseti moderately inhibited hepatitis C virus NS3/4A serine protease in vitro [116]; the known polyketide malformin C (119) isolated from the marine-derived fungus Aspergillus niger SCSIO JcswF30 potently inhibited HIV-1 infection in vitro [117]; the known marine β-carboline alkaloid manzamine A (120) isolated from the Indo-Pacific sponge Acanthostrongylophora sp.