Villa-Pérez and colleagues reported that the furanocembranolide diterpenoid leptolide (128) isolated from soft coral Leptogorgia alba improved insulin sensitivity by increasing intracellular insulin signaling in both liver and skeletal muscle tissues of a diet-induced obese mice model, a “preclinical model of insulin resistance”, concluding that “furanocembranolides as a new therapeutic class to treat Type 2 diabetes” [155]. This evidence concerns the gene INS and Insulin resistance.