Brust and colleagues identified a previously uncharacterized nine amino acid conorphin-T (211) from a Conus textile venom peptide library with selectivity for κ-opioid receptors (KOR) that led to the development of several novel KOR agonists, which potently inhibited splanchnic colonic nociceptors, thus, becoming promising leads “for the development of irritable bowel syndrome treatments” [228]. Here, OPRK1 is linked to irritable bowel syndrome.