AKT1 and diabetes mellitus: Kim and colleagues reported that the marine algal polyphenol dieckol (126), isolated from the marine brown alga Ecklonia cava attenuated blood glucose levels in the zebrafish model of hyperglycemia, an in vivo paradigm used to study chronic diseases, such as diabetes, by a mechanism that stimulated the protein kinase B (Akt) pathway, thus demonstrating the “anti-diabetic effect” of this compound [153].