BDNF and Parkinson disease: Two studies were reported by the same research group describing the neuroprotective and anti-inflammatory effects of the cembranolide analog 11-dehydrosinulariolide (11-de) (212) isolated from the soft coral Sinularia flexibilis: Feng and colleagues observed that 11-de increased the expression of BDNF in a neuroblastoma cell line in vitro and had a protective effect in both an in vivo zebrafish and rat Parkinson’s disease model, results that the investigators hoped would “help treat patients diagnosed with Parkinson’s disease” [229].