INS and type 2 diabetes mellitus: Xu and colleagues observed that a novel bromophenol bis (2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) (125) isolated from the red alga Odonthalia corymbifera, increased glucose uptake in vitro, decreased the expression of protein tyrosine phosphatase 1B, activated the insulin signaling pathway and in mice “significantly decreased the blood glucose”, thus, suggesting BDDE might be a “treatment of type-2 diabetes” [152].