IL4 and allergic disease: Jiao and colleagues investigated the “terpene-polyketide-pyridine hybrid” dysivillosin A (148) isolated from the South China Sea marine sponge Dysidea villosa that inhibited RBL-2H3 mast cell release of β-hexosaminidase, a marker of degranulation, as well as pro-inflammatory leukotriene B4 and IL-4 by suppressing the IgE/Syk signaling pathway, thus suggesting a “new chemotherapeutic scaffold targeting Syk-associated allergy” [173].