MYC and B-cell non-Hodgkin lymphoma: The chromosomal translocation that places the MYC gene in close proximity to the immunoglobulin heavy chain (IGH) enhancer regions is the hallmark feature of Burkitt lymphoma [53], and is also frequently observed in other mature B-cell lymphomas, most prominently in diffuse large B-cell lymphoma (DLBCL), where it is associated with disease aggressiveness and adverse prognosis [54].