Moreover, analysis of several gene expression datasets indicated that PKM2 expression was associated with poor prognosis in MM, as was also the case for several other key glycolysis genes, including pyruvate dehydrogenase kinase 1 (PDK1), monocarboxylate transporter 1 (MCT1, SLC16A1) and the extracellular matrix metalloproteinase inducer (EMMPRIN, CD147), of which the latter two are involved in lactate efflux, thereby regulating glycolytic flux in MM [83,84] (Figure 2). Here, PDK1 is linked to Miyoshi myopathy.