MAF can therefore directly regulate proteins involved in cell cycle regulation (CCND2), MM cell homing, migration and adhesion (ITGB7, CCR1), insulin growth Factor-1 (IGF1) mediated invasion (ARK5) and PI3K/AKT/mTORC signaling (DEPTOR) (Figure 3). This evidence concerns the gene NUAK1 and Miyoshi myopathy.