Of note, t(14;16) and t(14;20) were strongly associated with an apolipoprotein B mRNA editing enzyme (APOBEC) mutational signature and knockdown of c-MAF or MAFB resulted in downregulation of apolipoprotein B mRNA editing enzyme (APOBEC) proteins, suggesting a reciprocal relation between MAF and APOBEC that drives ongoing mutagenesis in these MM subsets [273,274]. This evidence concerns the gene MAFB and Miyoshi myopathy.