MYC and medulloblastoma: The knockdown of FBXW7 in the D425 and D458 cell lines increased c-MYC and abolished the PCM-075-induced loss of the c-MYC protein, supporting our conclusion that FBXW7 mediates the degradation of c-MYC, while PLK1 promotes c-MYC stabilization via the abrogation of the FBXW7 in MYC-amplified medulloblastoma cell lines (Figure 2e,f).