A stratified survival analysis showed that tumoral CD20+ TILs were significantly associated with a better prognosis in patients younger than 65 years, male patients, with tobacco or alcohol consumption, positive PD-L1 expression in more than 10% of tumor cells, tumors with negative expression of SOX2 or NANOG, high density of tumoral CD8+ TILs, low density of tumoral infiltration by CD68+ macrophages and low stromal infiltration by CD4+ TILs. The gene discussed is CD4; the disease is neoplasm.