IC50 value against MDA-MB-231 cells is 0.6 μM.IC50 values against H441 (wt-EGFR) and H1975 (EGFRT790M) are 0.75 μM and 0.83 μM, respectively.It suppressed tumorigenesis in lung cancer mouse xenograft in vivo and enhanced tumor inhibitory response in treatment with JAK2 inhibitor.It showed no apparent systematic toxicity in a 28-day rat study (at 37.5 mg/kg). The gene discussed is JAK2; the disease is neoplasm.