IC50 values against SiHa and MCF-7 cells (8.42 and 9.54 μM, respectively). It prevents resistance of MDA-MB-231 to doxorubicin and mitoxantrone.Cytotoxicity in a wide variety of human cancers, targeting IKK-β, and FAK 1 inhibitionIn a mouse xenograft model, it decreased tumor size in combination with docetaxel. The gene discussed is IKBKB; the disease is neoplasm.