MAPK8 and cancer: Andrographolide (373) having potent cytotoxic effects against various cancer cells, it has been reported that andrographolide (373) exerts the anti-cancer effects by modulating several cancer-related pathways and proteins including JNK-signaling pathway, NF-κB and PI3K signaling pathway, cyclins and cyclin-dependent kinases (CDKs), metalloproteinases (MMPs) and tumor suppressor proteins (p53 and p21) [206].