100 is a dual VEGFR3 and VEGFR2 inhibitor (VEGFR3 IC50 = 1.15 nM, VEGFR2 IC50 = 3.56 nM) and its anti-lymphangiogenic and anti-angiogenic ability was demonstrated both in 3D microfluidic tumor lymphangiogenesis assay and in vivo corneal assay. The gene discussed is KDR; the disease is neoplasm.