Following the elimination of Ov-CPI-2, due to its potential to generate autoimmune responses, the amino acid sequences of eight selected lead candidate vaccine proteins (Ov-103, Ov-RAL-2, Ov-ASP-1, Ov-ALT-1, and Ov-ALT-2, Ov-B20, Ov-RBP-1 and Ov-CHI-1) were retrieved from the UniProt database, analysed and used to design Ov-DKR-2, a novel multi-epitope vaccine candidate against onchocerciasis. The gene discussed is RBP1; the disease is onchocerciasis.